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All About CD14 Antibodies

CD14 is an acute-phase glycoprotein that binds to Gram-negative LPS. It is mostly found on macrophages, monocytes, and neutrophils. You can visit to know about Cd14 antibody online.

Types of Antibodies - Rapid Novor

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Soluble forms can be released or ejected from the cell surface. CD14 can accept LPS after its initial binding to LBP and can later transfer LPS to the TLR4/MD2 protein complex. 

LPS activation in TLR4 causes inflammatory activation. CD14 is also involved in responding to TLR3 ligands, phosphoinositides and ligands, and the surfactant proteins SP-A as well as SP-D.

CD14 gene plays a significant function in the signaling of the immune system's innate response as well as in the detection of pathogens that cause inflammation. It also plays a crucial function in detecting the presence of tuberculosis (TB) disease. 

It is an indicator for biomarkers that can help in predicting the prognosis for breast invasive ductal cancer with LN+ER/PR+Her2+. It is also linked to allergies, asthma, and croup.

CD14 is a phosphoinositol-linked, single-chain, human cell surface glycoprotein antigen that is found on most human peripheral blood monocytes, granulocytes and dendritic reticulum cells, and some tissue macrophages. CD14 could also be found within B cells. 

Forms of soluble CD14 can be found in urine and in serum. The antigen acts as an acceptor of LPS-binding protein complexes. The CD14 gene plays an essential function in the identification of pathogens that trigger inflammation and in the subsequent activation of the immune system's innate response.